Linkage analysis of British and Indian families with Von Recklinghausen neurofibromatosis.
نویسندگان
چکیده
Linkage analysis has been undertaken in two British and three South African Indian families with Von Recklinghausen neurofibromatosis. Eleven polymorphic DNA probes were studied, including both random DNA sequences and candidate oncogenes. Although no evidence for linkage of these probes to the disease was detected, substantial exclusion regions were established on six of the chromosomes studied.
منابع مشابه
Further exclusion data for the Von Recklinghausen neurofibromatosis gene: a genetic linkage study of 19 polymorphic markers.
Linkage analysis on a panel of 15 Von Recklinghausen neurofibromatosis (VRNF) families with 19 polymorphic markers was carried out using the computer programme M-Link. Our findings have excluded VRNF from a significant proportion of the genome.
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عنوان ژورنال:
- Journal of medical genetics
دوره 24 9 شماره
صفحات -
تاریخ انتشار 1987